Related Experiment Video
Updated: Mar 24, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury
Published on: March 9, 2019
A Model of Pressure, Oxygenation, and Perfusion Risk Factors for Pressure Ulcers in the Intensive Care Unit
Deborah Bly1, Marilyn Schallom2, Carrie Sona2
1Deborah Bly is a staff nurse in the medical intensive care unit, Marilyn Schallom is a clinical nurse specialist and research scientist in the Department of Research for Patient Care Services, Carrie Sona is a clinical nurse specialist in the surgical intensive care unit, and Dean Klinkenberg is lead statistical analyst in the Department of Research for Patient Care Services, Barnes-Jewish Hospital at Washington University, St Louis, Missouri. dcb9106@bjc.org.
Background:
Although most intensive care patients are at risk for pressure ulcers, not all experience such ulcers.
Objective:
To examine a model of variables related to extrinsic and intrinsic pressure on skin and underlying tissues, oxygenation, perfusion, and baseline comorbid conditions to identify risk factors associated with pressure ulcers in critically ill adults.
Method:
A retrospective chart review was conducted on patients identified by weekly rounds from January 2010 through October 2010 to determine the prevalence of pressure ulcers. Variables were analyzed via bivariate analysis and logistic regression for unit-acquired pressure ulcers.
Results:
Data on 345 patients with 436 intensive care admissions were reviewed. Variables were significant in each model category at P < .05. In the regression analysis of first admission only (n = 306), the model was significant (P < .001) and yielded correct classification of 86.3% of patients. For all intensive care admissions (n = 391), the model was significant (P < .001) and yielded correct classification of 83.9% of patients. In both models, 4 of the same variables were significant: any transport off the unit, number of days to bed change, systolic blood pressure less than 90 mm Hg, and use of more than 1 vasopressor. History of pulmonary disease and presence of a feeding tube were also significant in regression analyses.
Conclusions:
Several variables within the model of pressure, oxygenation, and perfusion were significantly associated with development of pressure ulcers.
Related Concept Videos
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
Peripheral Artery Disease IV: Nursing Management
Peptic Ulcer
Acute Coronary Syndrome V: Nursing Management

