Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long Division of Polynomials01:26

Long Division of Polynomials

575
Polynomial division is an essential algebraic process to simplify expressions and solve equations. Just as numerical division separates a number into quotient and remainder, polynomial long division partitions a polynomial into simpler components; in this context, the dividend is the polynomial being divided, the divisor is the expression dividing it, and the result is expressed in terms of a quotient and a remainder.The division begins by arranging the dividend and divisor in standard...
575
Synthetic Disvision of Polynomials01:28

Synthetic Disvision of Polynomials

286
Synthetic division is an efficient algorithmic approach for dividing a polynomial by a linear binomial of the form x - c, where c is a real number. This method is helpful due to its streamlined process, which avoids the more cumbersome steps involved in the traditional long division of polynomials. It simplifies computation and serves as a practical tool for evaluating polynomials and identifying their factors.To perform synthetic division, one begins by listing the coefficients of the...
286
The Y-to-Y Circuit01:19

The Y-to-Y Circuit

813
In a balanced four-wire wye-to-wye system, the arrangement involves wye-connected sinusoidal voltage sources and loads, connected through a neutral wire that links the neutral nodes of the source and load. The load impedance is connected across each phase of the load. The wye-connected source can be connected to the wye-connected load in four-wire and three-wire arrangements. A three-phase system is considered balanced when the load on each phase is equal, leading to uniform current flow and...
813
Current Dividers01:10

Current Dividers

1.2K
In parallel electrical connections, resistors are linked between the same pair of nodes, creating an equal voltage across each resistor. Kirchhoff's current law is applied to these connections, establishing that the sum of currents through these resistors equals the source current. Utilizing Ohm's law, the source current is determined as the product of the source voltage and the sum of the reciprocals of individual resistances. This relationship simplifies the process of finding the current...
1.2K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

4.0K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
4.0K
Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

1.6K
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SMCHD1 loss re-wires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells.

bioRxiv : the preprint server for biology·2026
Same author

DNA methylation landscapes in human cells and their chromatin determinants.

Ageing and cancer research & treatment·2026
Same author

UVA-induced DNA damage and mutations in human melanocytes: relevance for melanoma mutations.

Nucleic acids research·2025
Same author

SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts.

Nature communications·2025
Same author

CXXC5 stabilizes DNA methylation patterns in mouse embryonic stem cells.

Epigenomics·2024
Same author

SMCHD1 maintains heterochromatin and genome compartments in human myoblasts.

bioRxiv : the preprint server for biology·2024
Same journal

ZNRF3 and RNF43 are active monomeric E3 ubiquitin ligases that self-associate.

Science signaling·2026
Same journal

Allosteric ligands with distinct properties uncover tissue-specific physiological regulation mediated by free fatty acid receptor 2.

Science signaling·2026
Same journal

Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate.

Science signaling·2026
Same journal

The APC/C adaptor Cdh1 stabilizes STING to potentiate innate immune activation in renal cell carcinoma.

Science signaling·2026
Same journal

Fattening mother's milk with oxytocin.

Science signaling·2026
Same journal

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B.

Science signaling·2026
See all related articles

Related Experiment Video

Updated: Mar 24, 2026

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

3.5K

Properly dividing with YAP.

Gerd P Pfeifer1

  • 1Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA. gerd.pfeifer@vai.org.

Science Signaling
|March 3, 2016
PubMed
Summary
This summary is machine-generated.

The Hippo pathway's YAP protein has a new role in cell division, separate from its known gene-regulating function. This discovery suggests YAP is crucial for maintaining genomic stability during cell division.

More Related Videos

De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

9.7K
Measuring Replicative Life Span in the Budding Yeast
12:41

Measuring Replicative Life Span in the Budding Yeast

Published on: June 25, 2009

21.4K

Related Experiment Videos

Last Updated: Mar 24, 2026

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
09:55

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

3.5K
De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

9.7K
Measuring Replicative Life Span in the Budding Yeast
12:41

Measuring Replicative Life Span in the Budding Yeast

Published on: June 25, 2009

21.4K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The Hippo pathway regulates organ size by controlling the transcriptional coactivator YAP.
  • YAP typically functions by influencing gene transcription to inhibit cell proliferation.

Purpose of the Study:

  • To investigate the role of YAP during cytokinesis, the process of cell division.
  • To determine if YAP's function in cytokinesis is linked to its transcriptional activity.

Main Methods:

  • The study utilized cell-based assays to observe YAP's behavior during cytokinesis.
  • Researchers employed molecular techniques to assess YAP's transcriptional activity in parallel with its role in cell division.

Main Results:

  • YAP plays a significant role during cytokinesis, the final stage of cell division.
  • This function of YAP in cell division is independent of its known transcriptional coactivator activity.

Conclusions:

  • YAP has a novel, non-transcriptional role during cytokinesis.
  • This YAP function may be essential for ensuring genomic stability in dividing cells.