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Related Experiment Video

Updated: Mar 24, 2026

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

Imaging the Neocortex Functional Architecture Using Multiple Intrinsic Signals: Implications for Hemodynamic-Based

Amiram Grinvald, Dahlia Sharon, David Omer

Cold Spring Harbor Protocols

|March 3, 2016

Summary

This summary is machine-generated.

Optical intrinsic signal imaging offers high-resolution in vivo mapping of cortical columns. This technique enhances understanding of brain development, organization, and function, informing other neuroimaging methods.

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Last Updated: Mar 24, 2026

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

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Published on: December 12, 2012

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Area of Science:

Neuroscience
Optical Imaging
Brain Function

Background:

Optical imaging using intrinsic signals provides high spatial resolution (up to 20 µm) for in vivo studies.
This technique has advanced the understanding of cortical development, organization, and function.

Purpose of the Study:

To review the development of optical intrinsic signal imaging.
To discuss its applications and implications for other neuroimaging techniques.

Main Methods:

Review of the development of optical intrinsic signal imaging techniques.
Analysis of applications in studying cortical structures and functions in vivo.

Main Results:

Demonstrated high spatial resolution (up to 20 µm) for mapping cortical columns in vivo.
Provided insights into principles of cortical development, organization, and function.

Conclusions:

Optical intrinsic signal imaging is a powerful tool for neuroscience research.
Findings have implications for understanding and developing other neuroimaging modalities like fMRI.