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Present status of Accelerator-Based BNCT.

Andres Juan Kreiner1, Javier Bergueiro2, Daniel Cartelli1

  • 1Gerencia de Investigación y Aplicaciones, CNEA, Av Gral Paz 1499, 1650 San Martin, Argentina; Escuela de Ciencia y Tecnología, Universidad de San Martín, Argentina; CONICET, Argentina.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
|March 3, 2016
PubMed
Summary
This summary is machine-generated.

Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT) is advancing with new accelerator developments. The (9)Be(d,n)(10)B reaction at 1.4 MeV offers a viable option for treating deep-seated tumors with AB-BNCT.

Keywords:
Accelerator-Based BNCTDifferent nuclear reactions and accelerator typesWorldwide activity

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Area of Science:

  • Nuclear Physics
  • Medical Physics
  • Accelerator Technology

Background:

  • The advancement of Boron Neutron Capture Therapy (BNCT) is perceived to be critically dependent on the availability of hospital-based neutron sources.
  • Significant research and development efforts are underway globally to create suitable accelerators for BNCT applications.

Purpose of the Study:

  • To provide an updated global overview of the status of Accelerator-Based BNCT (AB-BNCT).
  • To evaluate different accelerator-based neutron production reactions and associated technologies for BNCT.

Main Methods:

  • Analysis of various charged-particle induced nuclear reactions for neutron generation, including (7)Li(p,n)(7)Be, (9)Be(p,n)(9)B, and (9)Be(d,n)(10)B.
  • Comparison of neutron spectra characteristics and target properties (thermo-mechanical, stability).
  • Review of worldwide accelerator development activities relevant to AB-BNCT, considering electrostatic accelerators, tandem accelerators, and RFQ/drift tube Linacs.

Main Results:

  • Beryllium (Be) targets offer superior thermo-mechanical properties and stable products compared to Lithium (Li).
  • The (9)Be(d,n)(10)B reaction at approximately 1.4 MeV, using a thin target, produces a suitable neutron spectrum for AB-BNCT with minimal accelerator energy requirements.
  • The (7)Li(p,n)(7)Be reaction, while effective, presents significant technological challenges with Li targets.

Conclusions:

  • The (9)Be(d,n)(10)B reaction at 1.4 MeV with a thin target is a realistic and promising option for AB-BNCT, particularly for treating deep-seated tumors.
  • Beryllium targets are a viable alternative to Lithium targets due to improved stability and material properties.
  • Continued development of accelerators like RFQ and drift tube Linacs is crucial for the clinical implementation of AB-BNCT.