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Updated: Mar 24, 2026
Neutron Radiography and Computed Tomography of Biological Systems at the Oak Ridge National Laboratory's High Flux Isotope Reactor
Published on: May 7, 2021
An improved neutron autoradiography set-up for (10)B concentration measurements in biological samples
Ian Postuma1, Silva Bortolussi1, Nicoletta Protti1
1Department of Physics, University of Pavia, Italy; National Institute of Nuclear Physics, INFN, Section of Pavia, Italy.
Aim:
Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA).
Background:
Therefore, a (10)B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations.
Materials And Methods:
This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions.
Results:
Calibration curves for both liquid and tissue samples were obtained.
Conclusions:
The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.
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