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Published on: July 28, 2010
Expression of P33(ING1b) Protein in Colorectal Cancer
Somayeh Fallahnezhad1, Mehdi Nikbakht2, Saeed Shokri3
1Department of Anatomical Sciences and Cell Biology, Medical Faculty, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
Abstract:
BACKGROUND Colorectal cancer (CRC) is the second most common malignancy in the world. However, its mortality rate can be reduced if diagnosed early. P33ING1b is a tumor suppressor protein, which plays a role in growth control and apoptosis. Suppression of p33(ING1b) is associated with the loss of cellular growth control. However, p33 (ING1b) expression in CRC and its correlations with clinicopathological factors have been less studied. The aim of this study was to examine p33(ING1b) expression in patients with CRC and evaluate its potential correlations with clinicopathological factors. METHODS P33(ING1b) protein expression was examined in 70 cases of CRC tissue samples and their corresponding neighboring normal tissues by immunhistochemistry. Moreover, p33(ING1b) expression in CRC and its correlations with clinicopathological variables including patients' sex and age, tumor type, location, stage, and differentiation grade were examined. RESULTS P33(ING1b) expression was significantly lower in tumor samples compared with the normal adjacent samples (p<0.002). CONCLUSION Low expression of P33(ING1b) in patients with colorectal cancer, may be an important molecular event in the pathogenesis of colorectal cancer. Our data suggest that reduced expression of p33(ING1b) may be contribute to tumor genesis and accompanied by the loss of cellular growth control. In fact cell growth is out of control in lower expression of P33 and dysfunctional program cell death. P33 expression might explain the etiology of CRC for reducing the expression of tumor suppressor proteins.
Insights
Reduced expression of the tumor suppressor protein p33(ING1b) is linked to colorectal cancer (CRC) development. Lower p33(ING1b) levels correlate with uncontrolled cell growth and may contribute to CRC pathogenesis.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide, with early diagnosis crucial for improved outcomes.
- The tumor suppressor protein p33(ING1b) is involved in regulating cell growth and apoptosis.
- The role and expression patterns of p33(ING1b) in CRC remain underexplored.
Purpose of the Study:
- To investigate the expression levels of p33(ING1b) in colorectal cancer tissues.
- To determine the correlation between p33(ING1b) expression and clinicopathological factors in CRC patients.
Main Methods:
- Immunohistochemistry was employed to assess p33(ING1b) protein expression.
- Seventy cases of CRC tissue samples and adjacent normal tissues were analyzed.
- Expression levels were correlated with patient demographics, tumor characteristics (type, location, stage, differentiation).
Main Results:
- p33(ING1b) protein expression was significantly lower in CRC tumor tissues compared to normal adjacent tissues (p<0.002).
Conclusions:
- Reduced p33(ING1b) expression is a potential molecular event in colorectal cancer pathogenesis.
- Decreased p33(ING1b) may contribute to tumor genesis by impairing cellular growth control and programmed cell death.
- p33(ING1b) downregulation could be a factor in the etiology of colorectal cancer.
