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Intraperitoneal meropenem for peritoneal dialysis peritonitis with Serratia marcescens immediately on commencing

P Bhave1, P Tregaskis1, R Walker2

  • 1Department of Nephrology, The Alfred Hospital, Australia.

New Microbes and New Infections
|March 3, 2016
PubMed

Insights

A patient developed multidrug-resistant Serratia marcescens peritonitis shortly after starting peritoneal dialysis. Intraperitoneal meropenem was effective, showing promise for treating such infections.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Microbiology

Background:

  • Peritoneal dialysis (PD) is a vital treatment for end-stage renal disease.
  • Infections, particularly peritonitis, are a significant complication of PD.
  • Multidrug-resistant organisms pose a growing challenge in PD-associated infections.

Observation:

  • A 67-year-old male patient initiated PD therapy.
  • Within one week, the patient developed peritonitis.
  • Dialysate cultures identified multidrug-resistant Serratia marcescens.

Findings:

  • The isolated multidrug-resistant Serratia marcescens strain was successfully treated.
  • Treatment involved intraperitoneal administration of meropenem.
  • This case demonstrates an effective therapeutic approach for PD peritonitis.

Implications:

  • Highlights the increasing problem of multidrug-resistant infections in PD patients.
  • Suggests intraperitoneal meropenem is a viable treatment option for ambulatory peritonitis.
  • Underscores the need for vigilant monitoring and tailored antibiotic strategies in PD care.
Keywords:
Intraperitoneal meropenemSerratia marcescensnon-Pseudomonas Gram-negative organismsperitoneal dialysisperitonitis

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