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Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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The Spinal Cord01:54

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The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Related Experiment Video

Updated: Mar 24, 2026

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
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2015 Relaunch as Open Access Pediatric Neurology Briefs.

John J Millichap1, J Gordon Millichap1

  • 1Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Pediatric Neurology Briefs
|March 3, 2016
PubMed
Summary
This summary is machine-generated.

Pediatric Neurology Briefs (PNB) is now an open access, peer-reviewed journal, enhancing its reach to healthcare providers. Future goals include digitization and PubMed inclusion for wider accessibility of pediatric neurology advancements.

Keywords:
Brain DiseasesChild DevelopmentNervous System DiseasesNeurologyPediatrics

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Area of Science:

  • Pediatric Neurology
  • Medical Education
  • Scholarly Publishing

Background:

  • Pediatric Neurology Briefs (PNB) has served as a monthly continuing education resource since 1987.
  • The publication aimed to streamline the review of pediatric neurology literature.

Purpose of the Study:

  • To relaunch Pediatric Neurology Briefs (PNB) as an open access, peer-reviewed journal in 2015.
  • To expand the journal's reach and improve its infrastructure for content management and accessibility.

Main Methods:

  • Transitioned PNB to an open access model.
  • Implemented a new website and content management system.
  • Expanded the editorial board.

Main Results:

  • Enhanced peer-review organization.
  • Improved indexing and DOI assignment.
  • Enabled online full-text article viewing.

Conclusions:

  • The relaunched PNB aims to disseminate pediatric neurology advances to a broader audience.
  • Future objectives include digitizing archives and indexing in PubMed.
  • The open access format facilitates wider access for physicians, researchers, and healthcare providers.