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Nucleolar protein 4-like has a complex expression pattern in zebrafish embryos
Supriya Borah1, Praveen Barrodia, Rajeeb K Swain
1Institute of Life Sciences, Nalco Square, Chandrasekhar Pur, Bhubaneswar, Odisha, India.
The International Journal of Developmental Biology
|March 3, 2016
Summary
The nucleolar protein 4-like (NOL4L) gene
Area of Science:
- Developmental Biology
- Genetics
- Molecular Biology
Background:
- The nucleolar protein 4-like (NOL4L) gene's function is largely unknown.
- NOL4L gene fusions are implicated in certain leukemias.
- Vertebrate developmental expression patterns of NOL4L homologs are unreported.
Purpose of the Study:
- To investigate the expression pattern of the zebrafish nol4l gene during embryogenesis.
- To understand the role of NOL4L during vertebrate development.
Main Methods:
- Zebrafish (Danio rerio) model organism.
- Whole-mount in situ hybridization to detect nol4l mRNA expression.
Main Results:
- Zebrafish nol4l mRNA is expressed in various embryonic tissues.
- Expression observed in the brain, spinal cord, pronephros, hematopoietic cells, and gut.
Conclusions:
- Zebrafish nol4l exhibits a broad expression pattern during embryogenesis.
- These findings provide a foundation for studying NOL4L function in development and disease.
