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Related Concept Videos

Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

Modified-Release Drug Delivery Systems: Influencing Factors

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Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
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Related Experiment Video

Updated: Mar 24, 2026

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device
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Stable Ultrathin-Shell Double Emulsions for Controlled Release.

Chun-Xia Zhao1,2, Dong Chen2, Yue Hui1

  • 1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD, 4072, Australia.

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
|March 3, 2016
PubMed
Summary
This summary is machine-generated.

Stable, biocompatible double emulsions using fish oil offer enhanced encapsulation and controlled release of hydrophilic molecules. Osmolarity shock triggers rapid release, overcoming stability limitations for diverse applications.

Keywords:
double emulsionsencapsulationinterfacesmicroreactorssurface chemistry

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Area of Science:

  • Food science
  • Materials science
  • Biotechnology

Background:

  • Double emulsions are typically metastable, limiting their use.
  • Conventional methods to stabilize them involve toxic solvents and high temperatures.
  • Complex processes like UV initiation are often required for polymer crosslinking.

Purpose of the Study:

  • To develop stable, biocompatible water-in-oil-in-water (W/O/W) double emulsions.
  • To investigate their potential for encapsulating and controlling the release of small hydrophilic molecules.
  • To explore a simple trigger for rapid release.

Main Methods:

  • Formation of W/O/W double emulsions utilizing an ultrathin fish oil layer.
  • Assessment of emulsion stability over time without external triggers.
  • Investigation of release kinetics triggered by osmolarity shock.

Main Results:

  • The developed double emulsions exhibited remarkable stability, lasting for months.
  • Encapsulated small hydrophilic molecules showed extremely slow release under normal conditions.
  • Complete and rapid release of molecules was achieved within 2 hours upon osmolarity shock.

Conclusions:

  • Biocompatible double emulsions with fish oil offer a stable platform for encapsulation.
  • Controlled release can be effectively triggered by osmolarity shock.
  • This approach overcomes traditional limitations, showing significant potential for food and drug applications.