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Thoracic stimulation and prolactin secretion.

L P Kapcala1, M C Lakshmanan

  • 1Department of Medicine, Case Western University School of Medicine, Cleveland Metropolitan General Hospital.

Journal of Endocrinological Investigation
|December 1, 1989
PubMed
Summary
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Thoracic stimulation from a cuirass can increase prolactin (PRL) secretion, but the effect is transient. This study investigated how mechanical thoracic pressure impacts dynamic PRL release in a patient with ventilatory muscle weakness.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Neuroendocrinology

Background:

  • Galactorrhea and elevated prolactin (PRL) levels are sometimes linked to thoracic stimuli.
  • The precise impact of thoracic stimulation on dynamic PRL secretion remains unclear.

Observation:

  • A patient with ventilatory muscle weakness presented with galactorrhea and intermittent hyperprolactinemia, coinciding with the use of a tight-fitting cuirass.
  • Serum PRL levels were measured during various conditions including brief and prolonged cuirass use, sleep, and pharmacological challenges.

Findings:

  • Both tight and loose cuirass use increased PRL levels, with a tighter cuirass causing an earlier peak.
  • Prolonged thoracic stimulation led to a transient PRL rise, returning to baseline despite continued stimulation.

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  • PRL secretion did not increase after sleep or insulin-induced hypoglycemia but showed an exaggerated response to TRH.

    • Implications:

    • Mechanical thoracic stimulation can transiently elevate PRL levels.
    • The dynamic regulation of PRL secretion in response to thoracic stimuli is complex.
    • Further research is needed to understand the neuroendocrine mechanisms involved.