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[Sex hormones and the skin]
1Centre de Recherche en Reproduction humaine (O.N.F.P.), Nouvelle Ariana, Tunisie.
Summary
Sex hormones significantly impact skin health, influencing collagen production and skin elements. Androgens, in particular, stimulate the epidermis, dermis, sebaceous glands, and hair growth.
Area of Science:
- Endocrinology
- Dermatology
- Reproductive Medicine
Context:
- The skin functions as a peripheral endocrine gland, actively metabolizing sex hormones.
- Growing recognition of the intricate relationship between sex hormones and cutaneous physiology.
Purpose:
- To review the cutaneous metabolism of estrogens, progestogens, and androgens.
- To analyze the effects of these hormones on skin structure and function.
- To explore the aetiopathogenic factors linking hyperandrogenism to reproductive disturbances.
Summary:
- Estrogens enhance skin collagen production.
- Androgens and progestogens with androgenic activity stimulate skin elements, including the epidermis, dermis, sebaceous glands, and hair.
- Skin manifestations of hyperandrogenism, such as anovulation, oligoamenorrhoea, and polycystic ovarian disease, stem from central nervous system dysfunction, hyperinsulinism, obesity-related hyperestronaemia, or adrenal hyperandrogenism.
Impact:
- Provides insights into the skin's role as an endocrine organ.
- Highlights the mechanisms underlying skin conditions associated with hormonal imbalances.
- Offers a foundation for understanding and potentially managing conditions like polycystic ovarian disease and hyperandrogenism.