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Updated: Mar 24, 2026
04:37
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
850
Resistant Hypertension
Adrian Doroszko1, Agnieszka Janus2, Ewa Szahidewicz-Krupska2
1Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Poland; Wrovasc - Integrated Cardiovascular Center, Research and Development Department, Provincial Specialist Hospital in Wrocław, Poland.
Summary
Resistant hypertension, affecting 9-18% of patients, requires careful diagnosis and treatment due to high cardiovascular risk. This summary covers identifying causes and therapeutic strategies for better management.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Resistant hypertension (RH) affects 9-18% of hypertensive patients, posing a significant cardiovascular risk.
- RH necessitates specialized diagnostic and therapeutic approaches due to its complex etiology and comorbidities.
Purpose of the Study:
- To summarize the identification of causes for resistant hypertension.
- To outline effective therapeutic strategies for managing resistant hypertension.
Main Methods:
- Exclusion of pseudohypertension, measurement errors, and white coat hypertension.
- Assessment of current antihypertensive drug regimens (ineffective use of ≥3 drugs including diuretics).
- Evaluation for secondary causes like obstructive sleep apnea, atherosclerosis, and renal/hormonal disorders.
Main Results:
- Multidrug therapy (ACE inhibitors, ARBs, beta-blockers, diuretics, CCBs, MRAs) is effective for RH.
- Innovative therapies like renal denervation and baroreflex activation offer new treatment avenues.
- Identifying and addressing secondary causes is crucial for effective RH management.
Conclusions:
- Accurate diagnosis of resistant hypertension involves excluding other conditions and identifying secondary causes.
- A comprehensive treatment strategy combining lifestyle changes, pharmacotherapy, and potentially novel interventions improves long-term outcomes.
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