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Related Concept Videos

Language and Cognition01:27

Language and Cognition

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Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
939

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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The relationship between microvasculature in white matter hyperintensities and cognitive function.

Jianzhong Sun1, Xinfeng Yu1, Yerfan Jiaerken1

  • 1Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Brain Imaging and Behavior
|March 4, 2016
PubMed
Summary

White matter hyperintensities (WMHs) are linked to cognitive decline. Intravoxel incoherent motion (IVIM) revealed altered microvasculature and microstructure in WMHs, with perfusion fraction (f) in periventricular WMHs correlating with better cognitive function.

Keywords:
Cerebral small vessel diseaseDiffusionIntravoxel incoherent motionMagnetic resonance imagingPerfusion

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Area of Science:

  • Neuroimaging
  • White Matter Hyperintensities
  • Cognitive Neuroscience

Background:

  • White matter hyperintensities (WMHs) are associated with cognitive decline.
  • The underlying pathophysiology linking WMHs to cognitive impairment requires further elucidation.

Purpose of the Study:

  • To investigate microvasculature and microstructure alterations in WMHs using intravoxel incoherent motion (IVIM).
  • To explore the association between IVIM-derived parameters and cognitive function in patients with WMHs.

Main Methods:

  • Thirty-two subjects with WMHs underwent IVIM imaging.
  • IVIM parameters (D*, f, D) were compared between WMH regions (PWMHs, DWMHs) and normal white matter.
  • Multivariate linear models assessed associations between IVIM parameters and Mini Mental State Examination (MMSE) scores.

Main Results:

  • WMHs showed significantly decreased fast diffusion coefficient (D*) and increased perfusion fraction (f) and slow diffusion coefficient (D) compared to normal white matter.
  • Increased f in periventricular WMHs (PWMHs) was independently associated with higher MMSE scores (β = 0.443, P = 0.016).

Conclusions:

  • IVIM analysis reveals distinct microvascular and microstructural changes within WMHs.
  • Increased perfusion fraction (f) in periventricular WMHs may represent a compensatory mechanism related to preserved cognitive function.