Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

42
Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
42
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

5.1K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
5.1K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.8K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.8K
Erythropoiesis01:14

Erythropoiesis

6.7K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
6.7K
Ferromagnetism01:31

Ferromagnetism

3.5K
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
3.5K
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

781
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
781

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of cross-mixing tests in differentiating etiologies of prolonged aPTT: a single-center retrospective study.

International journal of hematologyยท2026
Same author

Anemia visits and clinical patterns after identification of low hemoglobin at health checkups among women of reproductive age in Japan: a real-world claims and health checkup data study (AWARD study).

Current medical research and opinionยท2026
Same author

Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia.

Scientific reportsยท2026
Same author

Intervascular Large B-cell Lymphoma with Severe Anemia and a High-titer of Cold Agglutinin.

Internal medicine (Tokyo, Japan)ยท2025
Same author

Comparison of severe aplastic anaemia and lower risk hypoplastic myelodysplastic neoplasms: Critical role of megakaryocyte count in distinguishing aplastic anaemia from myelodysplastic neoplasms.

British journal of haematologyยท2025
Same author

Clustered peptide regulating the multivalent interaction between RANK and TRAF6 inhibits osteoclastogenesis by fine-tuning signals.

Communications biologyยท2025

Related Experiment Video

Updated: Mar 24, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K

[Iron-refractory iron deficiency anemia].

Hiroshi Kawabata1

  • 1Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|March 4, 2016
PubMed
Summary

Iron deficiency anemia (IDA) stems from blood loss, high iron needs, or poor absorption. A rare genetic form, iron-refractory IDA (IRIDA), results from TMPRSS6 mutations affecting hepcidin levels.

Area of Science:

  • Hematology
  • Genetics
  • Gastroenterology

Context:

  • Iron deficiency anemia (IDA) is a prevalent condition with diverse causes, including bleeding, increased requirements, and malabsorption.
  • Common IDA etiologies in Japan involve menstrual blood loss, autoimmune atrophic gastritis, and Helicobacter pylori infection.
  • A distinct genetic cause, iron-refractory IDA (IRIDA), arises from TMPRSS6 mutations.

Purpose:

  • To elucidate the mechanisms and diagnostic challenges of iron-refractory IDA (IRIDA).
  • To differentiate IRIDA from common IDA based on clinical and biochemical features.
  • To highlight the role of TMPRSS6 mutations in iron homeostasis disruption.

Summary:

  • IDA causes include bleeding, increased needs, and reduced intestinal absorption (e.g., H. pylori).

More Related Videos

Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example
12:44

Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example

Published on: December 3, 2014

55.1K
A Colorimetric Method for Measuring Iron Content in Plants
07:12

A Colorimetric Method for Measuring Iron Content in Plants

Published on: September 7, 2018

23.1K

Related Experiment Videos

Last Updated: Mar 24, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K
Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example
12:44

Electrophoretic Mobility Shift Assay EMSA for the Study of RNA-Protein Interactions: The IRE/IRP Example

Published on: December 3, 2014

55.1K
A Colorimetric Method for Measuring Iron Content in Plants
07:12

A Colorimetric Method for Measuring Iron Content in Plants

Published on: September 7, 2018

23.1K
  • IRIDA, caused by TMPRSS6 mutations, leads to elevated hepcidin, impairing iron supply to erythropoietic cells.
  • IRIDA presents as microcytic, hypochromic anemia but lacks low serum ferritin; it's refractory to oral iron.

    • Impact:

    • Understanding IRIDA's genetic basis is crucial for accurate diagnosis and management.
    • Genetic testing is essential for identifying IRIDA, which may otherwise be misdiagnosed.
    • This knowledge aids in differentiating genetic IDA forms from acquired ones, improving patient care.