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Updated: Mar 24, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Four Cytotoxic Spongian Diterpenes from the Sponge Dysidea cf. arenaria
Mika Shingaki1, Tsuyoshi Wauke, Peni Ahmadi
1Department of Chemistry, Biology and Marine Science, University of the Ryukyus.
Abstract:
Chemical analysis of the sponge Dysidea cf. arenaria from Irabu Island provided four new diterpenes 1-4. Their structures were elucidated by NMR and other spectroscopic analyses. All the metabolites retained the spongian skeleton and an isovalerate ester, but were different from those previously isolated from a specimen of Okinawa Island, implying geographic variation. The cytotoxicity of compounds 1-4 to NBT-T2 cells was evaluated and their IC50 values were 3.1, 1.9, 8.4, and 3.1 µM, respectively.
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