Musculoskeletal Pain and Vitamin D Deficiency in Children: A Pilot Follow-up Study of Vitamin D Therapy in

Z Blagojevic1, V Nikolic, D Kisic-Tepavcevic

  • 1Institute for Orthopedic Surgery "Banjica", Belgrade, Serbia.

Insights

Vitamin D therapy may reduce pain and improve daily functioning in children with musculoskeletal conditions and vitamin D deficiency. This pilot study suggests benefits for pain, mobility, and fatigue in pediatric patients.

Area of Science:

  • Pediatric Orthopedics
  • Nutritional Science
  • Pain Management

Background:

  • Vitamin D deficiency is prevalent in children.
  • Musculoskeletal/orthopedic conditions often involve chronic pain.
  • Vitamin D's role in pediatric musculoskeletal health requires further investigation.

Purpose of the Study:

  • To analyze associations between vitamin D therapy and pain, mobility, fatigue, and daily functioning.
  • To evaluate the impact of vitamin D supplementation in children with musculoskeletal disorders and vitamin D deficiency.
  • To assess outcomes in pediatric patients experiencing chronic pain.

Main Methods:

  • A 6-month prospective study involving children with musculoskeletal/orthopedic conditions and vitamin D deficiency.
  • Vitamin D supplementation was administered over the study period.
  • Self- and parent/proxy rating scales assessed pain, movement, fatigue, and daily functioning.

Main Results:

  • Significant decrease in worst pain intensity post-vitamin D therapy (p ≤ 0.03).
  • Improved functioning related to pain (p ≤ 0.01) reported by children.
  • Children reported enhanced movement, balance, and reduced fatigue; parents noted improved daily functioning.

Conclusions:

  • Vitamin D therapy may reduce pain and improve mobility and daily functioning in pediatric patients.
  • The study indicates potential benefits for children with chronic pain and vitamin D deficiency.
  • Further randomized studies are needed to confirm clinical recommendations.
Abstract

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.0K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
6.0K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.7K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.5K