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Published on: October 31, 2025
Early intervention leads to long-term developmental improvements in very preterm infants, especially infants with
Jwp Van Hus1, M Jeukens-Visser1, K Koldewijn1
1Department of Rehabilitation, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Insights
The Infant Behavioral Assessment and Intervention Program improved motor development in very preterm infants. Benefits were most significant for infants with bronchopulmonary dysplasia, showing gains in both cognitive and motor skills.
Area of Science:
- Developmental Pediatrics
- Neonatology
- Clinical Psychology
Background:
- Very preterm infants face high rates of neurodevelopmental problems.
- Early intervention programs are crucial for mitigating these issues.
- Longitudinal data is needed to assess the long-term impact of interventions.
Purpose of the Study:
- To evaluate the longitudinal effects of the Infant Behavioral Assessment and Intervention Program.
- To assess impacts on cognitive and motor development in very preterm infants.
- To examine outcomes from six months to five and a half years corrected age.
Main Methods:
- Randomized controlled trial with 176 very preterm infants (gestational age <32 weeks or birthweight <1500 g).
- Intervention group (n=86) received the program; control group (n=90) did not.
- Cognitive and motor development assessed using Bayley Scales, Wechsler Preschool and Primary Scale of Intelligence, and Movement Assessment Battery for Children.
Main Results:
- Significant longitudinal improvements in motor development (0.4 SD, p=0.006) were observed in the intervention group.
- No significant impact on overall cognitive development (p=0.063).
- Infants with bronchopulmonary dysplasia showed significant gains in both cognitive (0.7 SD, p=0.019) and motor (0.9 SD, p=0.026) outcomes.
Conclusions:
- The Infant Behavioral Assessment and Intervention Program promotes long-term developmental improvements.
- The intervention is particularly beneficial for very preterm infants with bronchopulmonary dysplasia.
- Maternal education showed minimal influence on intervention effects over time.
Aim:
Various early intervention programmes have been developed in response to the high rate of neurodevelopmental problems in very preterm infants. We investigated longitudinal effects of the Infant Behavioral Assessment and Intervention Program on cognitive and motor development of very preterm infants at the corrected ages of six months to five and a half years.
Methods:
This randomised controlled trial divided 176 infants with a gestational age <32 weeks or birthweight <1500 g into intervention (n = 86) and control (n = 90) groups. Cognitive development and motor development were assessed with the Bayley Scales of Infant Development at the CAs of six, 12 and 24 months and at five and a half years with the Wechsler Preschool and Primary Scale of Intelligence and the Movement Assessment Battery for Children.
Results:
We found significant longitudinal intervention effects (0.4 SD, p = 0.006) on motor development, but no significant impact on cognitive development (p = 0.063). Infants with bronchopulmonary dysplasia showed significant longitudinal intervention effects for cognitive (0.7 SD; p = 0.019) and motor (0.9 SD; p = 0.026) outcomes. Maternal education had little effect on intervention effects over time.
Conclusion:
The Infant Behavioral Assessment and Intervention Program led to long-term developmental improvements in the intervention group, especially in infants with BPD.
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