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Benzene exposure is associated with epigenetic changes (Review).

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Benzene exposure can alter gene regulation through epigenetic modifications like DNA methylation and histone changes. Understanding these epigenetic effects is key to predicting benzene

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Area of Science:

  • Environmental Health
  • Toxicology
  • Epigenetics

Background:

  • Benzene is a common air pollutant and industrial solvent.
  • Chronic benzene exposure is linked to aplastic anemia and leukemia.
  • Benzene's toxicity is associated with its metabolism and reactive intermediates.

Purpose of the Study:

  • To review epigenetic modifications correlated with benzene exposure.
  • To explore novel approaches for understanding benzene's impact on human health via gene regulation.
  • To summarize current literature on benzene's epigenetic effects.

Main Methods:

  • Computerized literature search in PubMed (November 2014).
  • Keywords used: 'benzene', 'epigenetic', 'histone modifications', 'DNA methylation', 'microRNA'.
  • Review of epidemiological and experimental studies.

Main Results:

  • Epidemiological and experimental studies confirm potential epigenetic effects of benzene exposure.
  • Observed epigenomic changes may link environmental exposures to disease susceptibility.
  • Benzene exposure can lead to alterations in DNA methylation and histone modifications.

Conclusions:

  • Epigenetic modifications are a promising area for understanding benzene toxicity.
  • Elucidating benzene's gene expression alterations can improve toxic potential prediction.
  • Further research can lead to targeted disease prevention strategies for benzene exposure.