Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Forage peanut legume as a strategy for improving beef production without increasing livestock greenhouse gas emissions.

Animal : an international journal of animal bioscience·2024

Same author

Effects of supplementation with corn distillers' dried grains on animal performance, nitrogen balance, and enteric CH<sub>4</sub> emissions of young Nellore bulls fed a high-tropical forage diet.

Animal : an international journal of animal bioscience·2021

Same author

Progressive inclusion of pearl millet herbage as a supplement for dairy cows fed mixed rations: Effects on methane emissions, dry matter intake, and milk production.

Journal of dairy science·2020

Same author

Editorial: Greenhouse gases in animal agriculture: science supporting practices.

Animal : an international journal of animal bioscience·2020

Same author

Greenhouse gas balance and carbon footprint of pasture-based beef cattle production systems in the tropical region (Atlantic Forest biome).

Animal : an international journal of animal bioscience·2020

Same author

Host-pathogen interaction in Toxoplasma gondii-infected mixed chicken blood cell cultures.

Parasitology research·2019

Same journal

Histomorphologic evidence supports a hyperplastic pathogenesis of fibromatous epulis of periodontal ligament origin/peripheral odontogenic fibroma and proposal of fibromatous hyperplasia of the gingival ligament as unifying nomenclature.

Veterinary pathology·2026

Same journal

Image challenge in <i>veterinary pathology</i>.

Veterinary pathology·2026

Same journal

Image challenge in veterinary pathology, answers: Bovine diseases.

Veterinary pathology·2026

Same journal

Immunohistochemical detection of the transcription factor osterix in canine and feline osteosarcoma.

Veterinary pathology·2026

Same journal

Spontaneous rhabdomyosarcomas in <i>Dmd</i><sup><i>mdx</i></sup> rats.

Veterinary pathology·2026

Same journal

Data set creation for supervised deep learning-based analysis of microscopic images: Review of important considerations and recommendations.

Veterinary pathology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 24, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study.

J P Sundberg¹, A Berndt², B A Sundberg³

¹The Jackson Laboratory, Bar Harbor, ME, USA john.sundberg@jax.org.

Veterinary Pathology

|March 4, 2016

Summary

This summary is machine-generated.

Inbred mice studies reveal diverse spontaneous diseases during aging, averaging 12 diagnoses per mouse. Genetic analysis identified candidate genes for age-related intestinal amyloidosis, offering translational benefits for human aging research.

Keywords:

aging genetics genome-wide association study intestinal amyloidosis mice

More Related Videos

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

Related Experiment Videos

Last Updated: Mar 24, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

Published on: August 4, 2018

Area of Science:

Aging research
Genetics
Pathology

Background:

Inbred mice offer genetic homogeneity and a shorter lifespan, making them ideal models for aging studies.
Extensive analytical tools and genomic data are available for mouse aging research.

Purpose of the Study:

To characterize the types and diversity of spontaneous diseases in aging inbred mice.
To utilize genomic data for genome-wide association studies (GWAS) to identify genes involved in disease pathogenesis.

Main Methods:

Histopathological analysis of 20,885 diagnoses across 28 diverse inbred mouse strains.
Genome-wide association study (GWAS) to investigate genetic links to age-related intestinal amyloidosis.

Main Results:

An average of 12 spontaneous diseases were diagnosed per mouse.
GWAS identified three candidate genes (Tram1, Sf3b5, Stx11) associated with intestinal amyloidosis.
Photomicrographs are available for reference in the Mouse Tumor Biology Database and Pathbase.

Conclusions:

Inbred mice develop a wide spectrum of spontaneous diseases during aging.
Genetic discoveries in mouse aging models have direct translational relevance to human diseases.
Candidate genes identified can further research into aging pathogenesis.