Ataxia in a chronic kidney disease patient on anti-tubercular therapy

Area of Science:

• Pharmacology
• Neurology
• Nephrology

Background:

• Isoniazid is a primary drug for tuberculosis treatment.
• It is generally safe, but neurotoxicity is a known side effect.

Observation:

• A patient with stage 5 chronic kidney disease developed severe neurological symptoms.
• These symptoms were linked to isoniazid therapy.

Findings:

• This case demonstrates a rare instance of significant neurotoxicity.
• The neurotoxicity occurred in the context of advanced chronic kidney disease.

Implications:

• Clinicians should consider rare neurological complications of isoniazid.
• Careful monitoring is crucial for patients with chronic kidney disease receiving anti-tubercular therapy.