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Updated: Mar 24, 2026

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Comprehensive data analysis of human ureter proteome.

Sameh Magdeldin1, Yoshitoshi Hirao2, Amr El Guoshy3

  • 1Biofluid Biomarker Center (BB-C), Institute for Research Collaboration and Promotion, Niigata University, Niigata, Japan; Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt; Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR11, La Jolla, CA 92037, United States.

Data in Brief
|March 4, 2016
PubMed
Summary

Researchers identified over 2,200 human ureter proteins, finding many in urine and 21 potentially unique to ureter tissue. This discovery aids in finding new biomarkers for ureter diseases like cancer.

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Area of Science:

  • Urology
  • Proteomics
  • Biomarker Discovery

Background:

  • The human ureter proteome remains largely uncharacterized.
  • Identifying ureter-specific proteins is crucial for understanding tissue function and disease pathology.

Purpose of the Study:

  • To create a comprehensive human ureter proteome dataset.
  • To identify potential urinary and ureter-specific proteins for biomarker discovery.

Main Methods:

  • Proteomic analysis of OFF-gel fractionated human ureter samples.
  • Comparison of identified ureter proteins against existing human protein databases (urinary bladder, prostate).
  • Gene Ontology (GO) annotation using Cytoscape for functional analysis.

Main Results:

  • A dataset of 2217 non-redundant ureter proteins was generated.
  • 751 proteins (33.8%) were identified in urine, including exosomal proteins.
  • 21 proteins were found to be potentially unique to ureter tissue compared to bladder and prostate.

Conclusions:

  • The generated ureter proteomic dataset is a valuable resource for urology research.
  • Findings suggest potential biomarkers for ureter diseases, including ureter carcinoma.
  • Further investigation into identified proteins can elucidate molecular functions and biological processes in the ureter.