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Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson's Disease
Izel Tekin1, Angeliki Vgontzas2, Mechelle M Lewis3
1Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Background:
Parkinson's disease (PD) motor symptoms are frequently asymmetric and the factors that influence the side of onset are unclear.
Objective:
To explore whether peripheral injury and associated chronic limb pain may influence the side of onset.
Methods:
We administered a questionnaire to 128 PD patients in a tertiary movement disorder clinic. Handedness, date and type of limb injury(s) and duration of associated pain, and date and side of onset were ascertained.
Results:
Sixty-two subjects reported limb injuries prior to the onset of PD symptoms, 30 with and 32 without chronic pain (i.e., ≥ 2 months). There was no association between injury and PD onset side overall (p=0.334). In subjects with chronic pain associated with limb injuries, however, side of injuries was associated with the side of PD symptom onset (p=0.030).
Conclusions:
Limb injury with chronic pain may be related to the side of PD symptom onset. Future studies may shed light on the nature of this observation.
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