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Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)

J S Pankow1, P A Decker2, C Berardi3

  • 1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.

Diabetic Medicine : a Journal of the British Diabetic Association
|March 4, 2016
PubMed

Insights

Elevated levels of certain soluble cellular adhesion molecules, including E-selectin and ICAM-1, are linked to an increased risk of developing diabetes. This suggests microvascular endothelial dysfunction may play a role in diabetes development.

Area of Science:

  • Cardiovascular disease and diabetes research
  • Endothelial function and metabolic health

Background:

  • Cellular adhesion molecules (CAMs) play a role in inflammation and endothelial function.
  • Endothelial dysfunction is implicated in the pathogenesis of diabetes.

Purpose of the Study:

  • To investigate the association between soluble cellular adhesion molecules and incident diabetes risk.
  • To test the hypothesis that soluble CAMs are independently associated with diabetes risk.

Main Methods:

  • Prospective cohort study (Multi-Ethnic Study of Atherosclerosis) with up to 10 years of follow-up.
  • Measurement of soluble levels of six CAMs: ICAM-1, E-selectin, VCAM-1, E-cadherin, L-selectin, and P-selectin.
  • Statistical analysis adjusted for age, sex, race/ethnicity, BMI, and glycemic markers.

Main Results:

  • Four CAMs (ICAM-1, E-selectin, VCAM-1, E-cadherin) were positively associated with incident diabetes.
  • Significant trends observed across quartiles of these CAMs.
  • E-selectin and ICAM-1 showed the largest associations with diabetes risk in fully adjusted models.

Conclusions:

  • Significant associations between multiple soluble CAMs and incident diabetes support the role of microvascular endothelial dysfunction in diabetes risk.
  • Findings may inform strategies for diabetes prevention and risk assessment.
Abstract

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