Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Primary structure of human C-reactive protein.

E B Oliveira, E C Gotschlich, T Y Liu

Proceedings of the National Academy of Sciences of the United States of America

|August 1, 1977

Summary

Researchers determined the full amino acid sequence for human C-reactive protein (CRP). They found distant similarities to complement proteins, strengthening known homologies between human CRP, rabbit CRP, and C1t protein.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Evaluation of the application and selection of surgical methods for gastroesophageal reflux caused by anatomical and functional abnormalities of the gastroesophageal junction].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025

Same author

[The 36th World Congress of Audiology summary and cutting-edge topics sharing].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025

Same author

[Preliminary study on the role and mechanism of IL-6 receptor antagonists in improving post-infarction ventricular arrhythmia].

Zhonghua xin xue guan bing za zhi·2024

Same author

[Ulcer intraluminal isolation in refractory duodenal ulcer with bleeding].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2023

Same author

[Efficacy and safety of neoadjuvant toripalimab combined with nimotuzumab and chemotherapy in patients with unresectable stage Ⅳ squamous cell carcinoma of penis].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2022

Same author

[The role of preventive pancreatic duct stent placement in preventing acute pancreatitis after endoscopic retrograde cholangiopancreatography].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2022

Area of Science:

Biochemistry
Immunology
Molecular Biology

Background:

Human C-reactive protein (CRP) is an acute-phase protein with known roles in inflammation and immunity.
Previous studies suggested homologies between CRP and complement system proteins, as well as immunoglobulins.

Purpose of the Study:

To establish the complete amino acid sequence of human C-reactive protein.
To identify and characterize homologies between human CRP and other known proteins, particularly within the complement and immunoglobulin systems.

Main Methods:

Amino acid sequencing of purified human C-reactive protein.
Bioinformatic analysis to compare the human CRP sequence with databases of known protein sequences.
Comparative analysis of conserved domains and homology regions.

Main Results:

The complete amino acid sequence of human C-reactive protein was elucidated.
Distant homologies were identified between human CRP and the C3 homology region within the CH2 domain of IgG.
Further homologies were noted with C3a anaphylotoxin, and previously reported similarities between human CRP, rabbit CRP, and C1t protein were confirmed and extended.

Conclusions:

The established amino acid sequence provides a foundation for understanding human CRP structure-function relationships.
The identified homologies suggest evolutionary or functional links between CRP, complement factors (like C3), and immunoglobulin domains.
Findings reinforce the evolutionary conservation and potential shared functional mechanisms among certain immune-related proteins.

Related Experiment Videos