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Calcium and cell death.

B K Siesjö1

  • 1Laboratory for Experimental Brain Research, Lund University Hospital, Sweden.

Magnesium
|January 1, 1989
PubMed
Summary

Calcium dysregulation threatens cell viability during energy deprivation. This review covers calcium

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Area of Science:

  • Cellular Biology
  • Neuroscience
  • Pathophysiology

Background:

  • Calcium homeostasis is crucial for cell viability.
  • Failure in calcium regulation occurs during anoxia and energy deprivation.
  • Disrupted calcium balance leads to cell damage and death.

Purpose of the Study:

  • To provide an overview of calcium-related cell damage.
  • To discuss cellular calcium homeostasis and its disruption.
  • To explore the role of calcium in neuronal vulnerability and ischemic damage.

Main Methods:

  • Literature review of calcium homeostasis and cell damage.
  • Discussion of various aspects of calcium's role in cell death.
  • Analysis of calcium influx, release, and entry routes.

Main Results:

  • Uncontrolled calcium influx or release compromises cell viability.
  • Calcium dysregulation is implicated in neuronal vulnerability to ischemia.
  • Excitatory amino acids contribute to calcium-mediated excitotoxicity.

Conclusions:

  • Loss of calcium homeostasis is a key factor in cell death.
  • Calcium plays a significant role in the pathogenesis of ischemic neuronal injury.
  • Understanding calcium's role is vital for addressing energy-deprived cell damage.

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