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Acute Respiratory Events in Connective Tissue Disorders
Spyros A Papiris1, Effrosyni D Manali, Likurgos Kolilekas
12nd Department of Pneumonology, x2018;Attikon' University Hospital, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Respiration; International Review of Thoracic Diseases
|March 4, 2016
Summary
Acute respiratory events are a major cause of death in connective tissue disorders (CTDs). Managing these severe lung complications requires specialized multidisciplinary care to improve patient survival.
Area of Science:
- Pulmonology
- Rheumatology
- Critical Care Medicine
Background:
- Connective tissue disorders (CTDs) frequently involve severe, life-threatening respiratory complications.
- These acute respiratory events can affect all lung compartments and precipitate extrapulmonary organ involvement.
- Lung involvement significantly contributes to morbidity and mortality in CTDs.
Purpose of the Study:
- To outline the spectrum of acute respiratory events in connective tissue disorders (CTDs).
- To emphasize the critical role of the lungs in CTD-related morbidity and mortality.
- To highlight the need for specialized multidisciplinary approaches in managing these complex cases.
Main Methods:
- Review of the literature on acute respiratory events in classic connective tissue disorders.
- Analysis of respiratory manifestations across different lung compartments (airways, parenchyma, vasculature, pleura, muscles).
- Consideration of associated factors including aspiration pneumonia, drug toxicity, and infections.
Main Results:
- Acute respiratory events in CTDs range from subacute to catastrophic, often leading to respiratory failure.
- These events can involve airways, lung parenchyma, capillaries, vessels, pleura, and ventilatory muscles.
- Associated complications include aspiration pneumonia, drug toxicity, and infections secondary to immunosuppression.
Conclusions:
- The lungs are a primary site for disease involvement, infection, and drug toxicity in CTDs.
- Effective management necessitates specialized diagnostic and therapeutic strategies.
- A multidisciplinary approach involving expert scientists is crucial for improving outcomes and potentially preventing lung disease in CTD patients.
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