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Bone Age and Serum Osteocalcin Levels in Children With Obstructive Sleep Apnea Hypopnea Syndrome Before and After

Hui-Wei Feng1, Yu-Dong Tian, Hong-Ping Zhang

  • 11Department of Otorhinolaryngology, the Second Hospital of Shandong University, Jinan, China; and 2Department of Orthopedic Surgery, the First Hospital of Jinan, Jinan, China.

American Journal of Therapeutics
|March 4, 2016
PubMed

Insights

Adenotonsillectomy (AT) in children with obstructive sleep apnea hypopnea syndrome (OSAHS) improved bone age and serum osteocalcin levels. These markers were lower in OSAHS patients pre-surgery and correlated with OSAHS severity.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Biochemistry

Background:

  • Obstructive sleep apnea hypopnea syndrome (OSAHS) in children can impact growth and development.
  • Serum osteocalcin is a key biomarker for bone metabolism.
  • Bone age assessment provides insights into skeletal maturation.

Purpose of the Study:

  • To investigate changes in bone age and serum osteocalcin levels in children with OSAHS before and after adenotonsillectomy (AT).
  • To explore the correlation between bone age, serum osteocalcin, and OSAHS severity indicators.

Main Methods:

  • A cohort of 58 children diagnosed with OSAHS underwent assessment of bone age (X-ray) and serum osteocalcin levels (ELISA) pre- and 6-months post-AT.
  • Statistical analysis was performed using SPSS 19.0.
  • Correlations were examined with apnea-hypopnea index, oxygen desaturation index, and Epworth sleepiness scale scores.

Main Results:

  • OSAHS patients exhibited significantly lower bone age and serum osteocalcin levels compared to normal controls prior to AT (P < 0.05).
  • Following AT, both bone age and serum osteocalcin levels significantly increased in OSAHS patients (P < 0.05).
  • Lower bone age and serum osteocalcin levels were negatively correlated with OSAHS severity indices (P < 0.05).

Conclusions:

  • Bone age and serum osteocalcin levels may be linked to the pathogenesis of pediatric OSAHS.
  • Adenotonsillectomy appears to be an effective intervention for improving bone maturation and osteocalcin levels in children with OSAHS.

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