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Diabetes and new-onset atrial fibrillation in a hypertensive population

Lia Alves-Cabratosa1, Maria García-Gil1,2, Marc Comas-Cufí1

  • 1a Vascular Health Research Group (ISV)-Girona, Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol) , Catalonia , Spain ;

Annals of Medicine
|March 5, 2016
PubMed

Insights

Diabetes modestly increases the risk of new-onset atrial fibrillation (AF) in hypertensive patients without prior vascular disease. Obesity was a significant factor among diabetic individuals with AF.

Area of Science:

  • Cardiology
  • Endocrinology
  • Epidemiology

Background:

  • The link between diabetes and new-onset atrial fibrillation (AF) is debated, with hypertension potentially mediating the association.
  • This study investigates the specific role of diabetes in hypertensive individuals without ischemic vascular disease.

Purpose of the Study:

  • To determine the association between diabetes and new-onset AF in hypertensive patients without ischemic vascular disease.
  • To explore characteristics of diabetes, including duration, treatment, HbA1c, and BMI, in relation to AF risk.

Main Methods:

  • A retrospective cohort study analyzed 262,892 hypertensive individuals aged ≥55 without ischemic heart disease, stroke, or peripheral artery disease.
  • Cox proportional hazards regression was used to compare AF incidence between diabetic and non-diabetic subgroups.
  • Factors like diabetes duration, pharmacological treatment, hemoglobin A1c, and body mass index were analyzed in diabetic patients.

Main Results:

  • New-onset AF incidence was 13.3 per 1000 person-years in diabetic patients versus 10.4 in non-diabetic patients.
  • Diabetes showed a modest hazard ratio (HR) of 1.11 for new-onset AF.
  • Diabetic patients with obesity had a significantly higher HR of 1.41 for new-onset AF.

Conclusions:

  • Diabetes is modestly associated with new-onset AF in hypertensive patients lacking ischemic vascular disease.
  • Among diabetic patients, obesity was the only significant factor associated with this arrhythmia.
Abstract

Keywords:
Atrial fibrillationdiabeteshypertension

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