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Insulin and vanadium protect against osteoarthritis development secondary to diabetes mellitus in rats

Abbas O El Karib1, Bahjat Al-Ani1, Fahaid Al-Hashem1

  • 1a Department of Physiology .

Archives of Physiology and Biochemistry
|March 5, 2016
PubMed
Abstract

Insights

Insulin and vanadium protect diabetic rats from osteoarthritis by reducing inflammation and oxidative stress. Combined treatment showed the greatest protective effect on cartilage and collagen fibers.

Area of Science:

  • Biomedical Science
  • Endocrinology
  • Orthopedics

Background:

  • Diabetic complications, including osteoarthritis (OA), pose significant public health challenges.
  • The impact of insulin on diabetes-related OA has not been previously studied in animal models.

Purpose of the Study:

  • To investigate the protective effects of insulin and vanadium, an insulin-mimicking agent, against osteoarthritis in diabetic rats.

Main Methods:

  • Type 1 diabetes mellitus (T1DM) was induced in Sprague-Dawley rats.
  • Rats were treated with insulin and/or vanadium.
  • Articular cartilage tissues were analyzed using scanning electron microscopy.
  • Blood samples were assessed for oxidative stress and inflammatory biomarkers.

Main Results:

  • Diabetic rats exhibited significant knee joint damage compared to controls.
  • Insulin and/or vanadium treatment protected against cartilage damage and collagen fiber deterioration.
  • The combination of insulin and vanadium demonstrated the highest potency, followed by insulin, then vanadium.
  • Treatment significantly reduced elevated levels of TNF-α, IL-6, and TBARS, while increasing SOD levels.

Conclusions:

  • Co-administration of insulin and vanadium protects against diabetes-induced osteoarthritis in T1DM rats.
  • This protection is likely mediated by the reduction of inflammation and oxidative stress biomarkers.
Keywords:
DiabetesT1DMinsulinosteoarthritisrat modelvanadium

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