Related Experiment Video
Updated: Mar 24, 2026

Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
Published on: September 20, 2024
Do biofilms confer a pro-carcinogenic state?
Christine M Dejea1, Cynthia L Sears1,2
1a Department of Oncology , Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions , Baltimore , MD , USA.
Abstract:
It is now widely recognized that a range of human diseases, including obesity, cancer and inflammatory bowel disease, is strongly linked to the microbiota. For decades, the microbiota has been proposed to contribute to the pathogenesis of colon cancer. Our recent work reveals that the organization of the mucosal microbiota into biofilms marks a subset of human colon cancer. Further, biofilm-positive colon mucosa in the colon cancer host yields an infrequently detected polyamine metabolite, N(1), N(12)-diacetylspermine, that deserves further study to determine its utility as a marker for colon neoplasia.
Related Concept Videos
Biofilms
Mutagenicity and Carcinogenicity
Colonisation of Pathogens
Gene Regulation in Microbial Communities: Quorum Sensing
Bacterial Signaling
Cancer Prevention
Some...

