Positive TTF-1 Expression in Malignant Mesothelioma: A Case Report
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Updated: Mar 24, 2026
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
Georg Richter1, Holger Heidersdorf2, Dieter Hirschfeld3
1, Institute of Pathology, Hameln, Germany.
Background:
The histopathological diagnosis of malignant mesothelioma is based mainly on the immunohistological profile of the neoplasia, using different immunohistochemical markers to distinguish between a malignant mesothelioma and a carcinoma.
Case Report:
A female patient presented with a right paravertebral rapidly growing tumor and severe pain. Based on the immunohistochemical findings, we present the first case of a malignant mesothelioma with immunohistochemical expression of thyroid transcription factor-1.
Conclusions:
The detection of a positive reaction for thyroid transcription factor-1 in the tumor cells may not exclude a malignant mesothelioma.
