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Thermo-responsive hydrogels from cellulose-based polyelectrolytes and catanionic vesicles for biomedical application.

Gesmi Milcovich1, Filipe Antunes2, Samuel Golob3

  • 1Department of Chemical and Pharmaceutical Sciences, University of Trieste, via L. Giorgieri 1, Trieste, I-34127, Italy.

Journal of Biomedical Materials Research. Part A
|March 5, 2016
PubMed
Summary
This summary is machine-generated.

Negatively charged vesicles and modified cellulose polymers form thermo-responsive hydrogels. These novel materials act as multifunctional junctions, enabling tunable properties for advanced applications like multi-drug delivery systems.

Keywords:
NMRcatanionic vesiclescellulosediffusionhydrogelrheology

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomaterials Engineering

Background:

  • Hydrogels are versatile materials with applications in drug delivery and tissue engineering.
  • Thermo-responsive hydrogels offer tunable properties based on temperature changes.
  • Catanionic vesicles can serve as building blocks for complex hydrogel networks.

Purpose of the Study:

  • To fabricate and characterize thermo-responsive hydrogels using catanionic vesicles and hydrophobically modified hydroxyethylcellulose.
  • To investigate the role of electrostatic and hydrophobic interactions in network formation.
  • To explore the potential of these hydrogels as multi-drug delivery systems.

Main Methods:

  • Fabrication of negatively charged catanionic vesicles and hydrophobically modified hydroxyethylcellulose.
  • Networking of polymer solutions using vesicular aggregates as junctions.
  • Evaluation of electrostatic and hydrophobic interactions by varying vesicle composition and polymer substitution.
  • Characterization of thermal-induced changes in vesicle size, lamellarity, and hydrogel mechanical behavior.
  • Molecular insights into polymer chain arrangement on vesicle surfaces.

Main Results:

  • Vesicular aggregates effectively networked modified-cellulose solutions.
  • Electrostatic and hydrophobic interactions significantly influenced network formation.
  • Thermo-responsive changes in vesicle size, lamellarity, and polygonal shape were observed.
  • Hydrogel mechanical properties were tunable via thermal transitions.
  • Successful determination of polymer chain arrangement on vesicle surfaces.

Conclusions:

  • The fabricated vesicularly cross-linked hydrogels exhibit significant thermo-responsive characteristics.
  • These hydrogels provide diverse microenvironments for guest molecules, suitable for multi-drug delivery.
  • The study demonstrates a novel approach for creating advanced biomaterials with tunable properties.