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Published on: July 5, 2017
(-)-Epicatechin in vitro ameliorates erythrocyte protein carbonyl content in hypertensive patients: comparison with
Navneet Kumar1,2, Pawan Kumar Maurya3,4, Ruchi Kant5
1a School of Medicine, College of Medicine and Health Sciences, Wollo University , Dessie , Ethiopia .
Context:
Oxidative stress plays a key role in the patho-physiology of hypertension. (-)-Epicatechin has many important biological properties.
Objective:
The present study was undertaken to evaluate effect of (-)-epicatechin on protein carbonyl content in gender-based hypertensive patients and normal subjects.
Methods:
The study was carried out on 83 normal (male: 42; female: 41) and 62 hypertensive subjects (male: 32; female: 30). In vitro effect on (-)-epicatechin and L-ascorbic acid was estimated on protein carbonyl content.
Results:
Result showed a significant (p < 0.001) increase in protein carbonyl content in hypertensive patients but no gender-based difference was observed. (-)-epicatechin shows significant (p < 0.001) dose-dependent effect as compared to L-ascorbic acid, which is manifested as decrease in protein carbonyl content.
Conclusion:
We hypothesizes that a higher intake of (-)-epicatechin may provide protection against hypertension in males and females.
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