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Updated: Mar 24, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
B-cell Non-Hodgkin Lymphomas with Plasmacytic Differentiation
Charles M Harmon1, Lauren B Smith2
1Department of Pathology, University of Michigan Hospitals and Health Systems, 1301 Catherine Street, Ann Arbor, MI 48109, USA.
B-cell non-Hodgkin lymphomas with plasmacytic differentiation present diagnostic challenges. Immunohistochemistry and molecular testing aid in classifying these diverse lymphomas, distinguishing low-grade from high-grade types.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- B-cell non-Hodgkin lymphomas with plasmacytic differentiation exhibit significant morphologic variability.
- Accurate classification is crucial for patient prognosis and treatment selection.
Purpose of the Study:
- To highlight the diagnostic challenges in differentiating various B-cell lymphomas with plasmacytic differentiation.
- To emphasize the utility of ancillary studies in accurate lymphoma subtyping.
Main Methods:
- Review of morphologic features of B-cell lymphomas with plasmacytic differentiation.
- Application of immunohistochemical studies.
- Utilization of molecular testing for classification.
Main Results:
- Lymphoplasmacytic lymphoma can be mistaken for marginal zone lymphoma or other low-grade B-cell lymphomas.
- Plasmablastic lymphomas may be confused with diffuse large B-cell lymphoma or other high-grade lymphomas.
Conclusions:
- Immunohistochemistry and molecular testing are essential tools for precise classification.
- Appropriate classification of these lymphomas improves diagnostic accuracy and patient management.
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