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The Expanding Spectrum of Follicular Lymphoma
1University of North Carolina School of Medicine, Department of Pathology and Laboratory Medicine, NC Cancer Hospital C3162-D, 101 Manning Drive, Chapel Hill, NC 27599, USA.
Abstract:
Follicular lymphoma is a far more heterogeneous entity than originally appreciated. Clinical and biological variants are increasingly more granularly defined, expanding the spectrum of disease. Some variants associate with age, whereas others with anatomic site. Identification of these biologically distinct diseases has real prognostic and predictive value for patients today and likely will be more relevant in the future. Understanding of follicular lymphoma precursors has also made their identification both scientifically and clinically relevant. This review summarizes the features and understanding of follicular lymphoma, variants, and precursor lesions.
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