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A Simple Red Blood Cell Lysis Method for the Establishment of B Lymphoblastoid Cell Lines

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Transformation in Low-grade B-cell Neoplasms.

Nathan D Montgomery¹, Stephanie P Mathews¹

¹Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, CB #7525, Chapel Hill, NC 27599-7525, USA.

Surgical Pathology Clinics

|March 5, 2016

Summary

Histologic transformation in low-grade B-cell lymphomas can lead to aggressive disease. This review focuses on follicular lymphoma and chronic lymphocytic leukemia transformations, detailing their key features.

Keywords:

CLL/SLL Clonality Follicular lymphoma Low-grade lymphoma Richter syndrome Transformation

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Area of Science:

Hematology
Oncology
Pathology

Background:

Low-grade B-cell leukemias/lymphomas are typically indolent with good prognoses.
A subset of these disorders can transform into higher-grade neoplasms, leading to aggressive disease and poor survival.
Follicular lymphoma and chronic lymphocytic leukemia transformations are the most common and well-documented.

Purpose of the Study:

To review the clinical and pathologic characteristics of common transformations in low-grade B-cell lymphomas.
To highlight key histologic, immunophenotypic, and genetic features of these transformed neoplasms.

Main Methods:

Literature review of common transformations of low-grade B-cell lymphomas.
Emphasis on clinical presentation, histopathology, immunophenotyping, and genetic analysis.

Main Results:

Transformation to higher-grade lymphomas signifies a more aggressive clinical course.
Key diagnostic features for follicular lymphoma to diffuse large B-cell lymphoma transformation are discussed.
Salient features of Richter transformation in chronic lymphocytic leukemia/small lymphocytic lymphoma are detailed.

Conclusions:

Understanding transformation is crucial for managing patients with low-grade B-cell lymphomas.
Accurate identification of transformation requires integrated analysis of clinical, histologic, immunophenotypic, and genetic data.
Further research into the mechanisms and targeted therapies for lymphoma transformation is warranted.