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Myeloid Neoplasms with Germline Predisposition: A New Provisional Entity Within the World Health Organization
David R Czuchlewski1, LoAnn C Peterson2
1Department of Pathology, University of New Mexico, 1001 Woodward Place NE, Albuquerque, NM 87102, USA.
Abstract:
The forthcoming update of the World Health Organization (WHO) classification of hematopoietic neoplasms will feature "Myeloid Neoplasms with Germline Predisposition" as a new provisional diagnostic entity. This designation will be applied to some cases of acute myeloid leukemia and myelodysplastic syndrome arising in the setting of constitutional mutations that render patients susceptible to the development of myeloid malignancies. For the diagnostic pathologist, recognizing these cases and confirming the diagnosis will demand a sophisticated grasp of clinical genetics and molecular techniques. This article presents a concise review of this new provisional WHO entity, including strategies for clinical practice.
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