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The prevalence of functional dyspepsia using Rome III questionnaire among chronic hepatitis C patients
Hala I Mohamed1, Hamdy A Mokarib2, Zienab M Saad3
1Faculty of Medicine, Gastroenterology and Endemic Medicine Department, Minya University, Minya, Egypt. halaibrahem@mu.edu.eg.
Insights
Functional dyspepsia (FD) is more common in patients with chronic Hepatitis C virus (HCV) infection. Higher fibrosis scores and obesity are linked to increased FD prevalence in these patients.
Area of Science:
- Gastroenterology
- Hepatology
- Infectious Diseases
Background:
- Hepatitis C virus (HCV) infection frequently causes fatigue and abdominal pain.
- Functional dyspepsia (FD) is a common gastrointestinal disorder.
- The relationship between HCV and FD requires further investigation.
Purpose of the Study:
- To determine the prevalence of functional dyspepsia (FD) in patients with chronic Hepatitis C virus (HCV) infection.
- To identify factors associated with FD in HCV patients.
Main Methods:
- A case-control study involving 252 patients with chronic HCV and 150 healthy controls.
- Rome III criteria questionnaire administered to assess FD.
- Clinical, laboratory data, fibrosis scores, and BMI were recorded.
Main Results:
- FD prevalence was significantly higher in HCV patients (65.9%) compared to controls (28.7%).
- Postprandial distention syndrome was the predominant FD subtype in HCV patients (86.1%).
- Higher fibrosis scores (F2-3) and elevated ALT levels were associated with FD in HCV patients.
Conclusions:
- Functional dyspepsia is more prevalent in individuals with chronic Hepatitis C virus infection.
- Obesity and advanced fibrosis are significant risk factors for developing FD in HCV patients.
Background:
Hepatitis C virus (HCV) is a common chronic infection that is widely associated with symptoms of fatigue and abdominal pain. The aim of the present study was to determine the prevalence of functional dyspepsia (FD) among patients with hepatitis C.
Methods:
This study included 252 patients with chronic hepatitis C and 150 healthy volunteers. Clinical and laboratory data were recorded for every patient. All patients and controls were administered a questionnaire of FD according to Rome III criteria.
Results:
The percentage of patients with FD was significantly higher in patients with chronic HCV than normal controls (65.9 % vs 28.7 %, respectively). In chronic HCV patients, post prandial distention syndrome (PDS) subtype was the predominant type (86.1 %). The percentage of patients with a high fibrosis score (F2-3) and raised ALT were significantly higher in patients with FD than in patients without FD (P < 0.001; P < 0.04; respectively). A multivariate regression analysis revealed a significant association between fibrosis score, BMI and FD CONCLUSION: FD is more prevalent in patients with chronic hepatitis C. Obese chronic HCV and those with higher fibrosis scores are more likely to have FD.
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