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Updated: Mar 24, 2026

Culturing Microglia from the Neonatal and Adult Central Nervous System

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

Nutrients, Microglia Aging, and Brain Aging.

Zhou Wu¹, Janchun Yu², Aiqin Zhu³

¹Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.

Oxidative Medicine and Cellular Longevity

|March 5, 2016

Summary

This summary is machine-generated.

Systemic inflammation accelerates cognitive decline by promoting microglia aging. Antioxidant nutrients may offer a nutritional strategy to support healthy brain aging and reduce Alzheimer's disease risk.

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Culturing Microglia from the Neonatal and Adult Central Nervous System

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Published on: August 9, 2013

Obtaining Human Microglia from Adult Human Brain Tissue

Obtaining Human Microglia from Adult Human Brain Tissue

Published on: August 30, 2020

Mitochondrial Preparation from Microglia for Glycan Analysis

Mitochondrial Preparation from Microglia for Glycan Analysis

Published on: May 30, 2025

Area of Science:

Neuroscience
Immunology
Gerontology

Background:

Increasing life expectancy worldwide highlights the growing problem of cognitive decline, particularly Alzheimer's disease (AD).
Systemic inflammation activates microglia, the brain's immune cells, leading to neuroinflammation and cognitive impairment.
Microglia aging is proposed as a key factor in age-related cognitive decline.

Purpose of the Study:

To review the concept of "microglia aging" and its link to systemic inflammation and cognitive decline.
To discuss the role of oxidative stress in promoting microglia aging.
To explore the potential of nutritional interventions for healthy brain aging.

Main Methods:

Review of existing research on microglia, inflammation, oxidative stress, and cognitive function.
Analysis of age-dependent microglial responses to chronic systemic inflammation.
Discussion of the impact of nutrients on inflammation and brain health.

Main Results:

Chronic systemic inflammation induces age-dependent microglial responses, correlating with learning and memory deficits.
Inflammation-induced oxidative stress and DNA damage contribute to the overproduction of inflammatory mediators, accelerating microglia aging.
Antioxidant nutrients show potential in reducing both systemic and neuroinflammation.

Conclusions:

Microglia aging is a significant contributor to cognitive decline and brain aging.
Controlling microglia aging through nutritional approaches may offer a novel strategy for promoting healthy brain aging and mitigating Alzheimer's disease progression.