Related Experiment Video
Updated: Mar 24, 2026

Author Spotlight: Eco-friendly Photoluminescent Textile Authentication with Curcumin
Published on: December 22, 2023
Oral bioavailability of curcumin: problems and advancements
Weidong Liu1, Yingjie Zhai2, Xueyuan Heng3
1a Department of Pharmacy , Linyi People's Hospital Affiliated to Shandong University , Linyi , China ;
Abstract:
Curcumin is a natural compound of Curcuma longa L. and has shown many pharmacological activities such as anti-inflammatory, anti-oxidant in both preclinical and clinical studies. Moreover, curcumin has hepatoprotective, neuroprotective activities and protects against myocardial infarction. Particularly, curcumin has also demonstrated favorite anticancer efficacy. But limiting factors such as its extremely low oral bioavailability hampers its application as therapeutic agent. Therefore, many technologies have been developed and applied to overcome this limitation. This review described the main physicochemical properties of curcumin and summarized the recent studies in the design and development of oral delivery systems for curcumin to enhance the solubility and oral bioavailability, including liposomes, nanoparticles and polymeric micelles, phospholipid complexes, and microemulsions.
Related Concept Videos
Bioavailability: Overview
Bioavailability: Overview
Factors Influencing Bioavailability: First-Pass Elimination
Bioavailability: Influencing Factors
Modified-Release Drug Delivery Systems: Bioavailability
Bioavailability Study Design: Absolute Versus Relative Bioavailability

