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Updated: Mar 24, 2026
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Published on: July 14, 2023
Management of Hypoparathyroidism: Summary Statement and Guidelines
Maria Luisa Brandi1, John P Bilezikian1, Dolores Shoback1
1Department of Surgery and Translational Medicine (M.L.B.), University of Florence, 50121 Florence, Italy; Columbia University College of Physicians & Surgeons (J.P.B.), New York, New York 10032; Endocrine Research Unit (D.S.), San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; Clinic and Laboratory of Experimental Endocrinology (R.B.), Gasthuisberg, KU Leuven, 3000 Leuven, Belgium; Mayo Clinic (B.C.), Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Rochester, Minnesota 55905; Academic Endocrine Unit (R.V.T.), Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom; McMaster University Calcium Disorders Clinic (A.A.K.), Hamilton, Canada L8S4L8; and Massachusetts General Hospital (J.T.P.), Boston, Massachusetts 02114.
This report summarizes current knowledge on hypoparathyroidism, a rare disorder causing hypocalcemia due to deficient parathyroid hormone (PTH). It proposes guidelines for diagnosis, evaluation, and management to aid clinicians.
Area of Science:
- Endocrinology
- Rare Diseases
- Metabolic Disorders
Background:
- Hypoparathyroidism is characterized by low calcium levels and insufficient parathyroid hormone (PTH).
- Managing this rare endocrine disorder presents unique clinical challenges.
Purpose of the Study:
- To synthesize current information on hypoparathyroidism epidemiology, presentation, diagnosis, and management.
- To propose evidence-based guidelines for clinical practice and future research.
Main Methods:
- A consensus-based approach involving an international conference and expert panel.
- Extensive literature review and synthesis of presentations and discussions.
Main Results:
- The report provides a comprehensive summary of the disorder.
- Guidelines are proposed to assist clinicians in diagnosing and managing hypoparathyroidism.
Conclusions:
- This document advances the understanding and management of hypoparathyroidism.
- It aims to foster future research and improve patient outcomes.
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