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Updated: Mar 24, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
Nigral involvement in atypical parkinsonisms: evidence from a pilot study with ultra-high field MRI
Daniela Frosini1, Roberto Ceravolo1, Michela Tosetti2
1Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Abstract:
Ten healthy subjects (HS) and 15 patients with atypical parkinsonisms underwent 7-T susceptibility-weighted-imaging MR to evaluate substantia nigra (SN). All HS were judged "normal". Twelve out of 15 patients exhibited bilateral abnormal SN while three patients with corticobasal degeneration (CBD) showed bilateral normal aspect of SN. Anatomical changes of SN at 7 T occur in multiple system atrophy and progressive supranuclear palsy as previously reported in Parkinson's disease. Preserved SN in CBD confirms the pathological heterogeneity of this disease.
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