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Updated: Mar 24, 2026
High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment
Serena Martire1, Nicole D Navone2, Francesca Montarolo1
1AOU San Luigi Gonzaga, Neurologia 2 - CReSM (Regional Referring Center of Multiple Sclerosis), Neurobiology Unit, Orbassano, TO, Italy; Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, TO, Italy.
Abstract:
We studied the baseline expression level of 25 interferon-regulated genes (MxA, GPR3, IL17RC, ISG15, TRAIL, OASL, IFIT1, IFIT2, RSAD2, OAS3, IFI44L, TRIM22, IL10, CXCL10, STAT1, OAS1, OAS2, IFNAR1, IFNAR2, IFNβ, ISG20, IFI6, PKR, IRF7, USP18), recurrently proposed in the literature as predictive biomarkers of interferon-beta treatment response, in whole blood of 10 "responders" and 10 "non-responders" multiple sclerosis relapsing-remitting patients, retrospectively selected on the basis of stringent clinical criteria after a five years follow-up. However, we cannot confirm the predictive value of these candidate biomarkers.
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