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Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study

Carolyn Wayne1, Jui-Hsia Cleo Hung1, Emily Chan1

  • 1Department of Pediatric Surgery, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

Journal of Pediatric Surgery
|March 6, 2016
PubMed

Insights

Infants fed exclusively formula have a significantly higher risk of developing infantile hypertrophic pyloric stenosis (HPS). This study suggests formula feeding is a risk factor for HPS, warranting further investigation into protective breast milk components.

Area of Science:

  • Pediatric Gastroenterology
  • Neonatal Health
  • Epidemiology

Background:

  • The exact causes of infantile hypertrophic pyloric stenosis (HPS) remain unclear.
  • This study investigated a potential link between formula feeding and increased HPS incidence.

Purpose of the Study:

  • To determine if formula feeding is associated with a higher incidence of infantile hypertrophic pyloric stenosis (HPS).

Main Methods:

  • A case-control study was conducted between 1992 and 2012.
  • Data on feeding methods were collected from patient charts for HPS cases and controls.

Main Results:

  • Infants with HPS were more likely to be exclusively formula-fed, male, and have a family history.
  • Exclusively formula-fed infants showed a 1.36 times higher risk of developing HPS compared to exclusively breastfed infants (RR 1.36, 95% CI 1.18-1.57).
  • Highest HPS incidence was observed during summer months.

Conclusions:

  • Formula feeding is significantly associated with an increased risk of infantile hypertrophic pyloric stenosis (HPS).
  • Further research is needed to identify specific formula components that may promote pyloric muscle hypertrophy or protective elements in breast milk.
Abstract

Keywords:
BreastfeedingFormula-feedingHypertrophic pyloric stenosisInfant

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