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Testing an anxiety process biomarker: Generalisation from an auditory to a visual stimulus.
Shabah M Shadli1, Melissa J Smith1, Paul Glue2
1Dept. Psychology, University of Otago, Dunedin, New Zealand.
Biological Psychology
|March 6, 2016
Summary
A new visual stop signal task (SST) detects an anxiolytic-sensitive biomarker, goal conflict specific rhythmicity (GCSR), in EEG. While promising for hearing-impaired individuals, further development is needed for quantitative equivalence with auditory tasks.
Area of Science:
- Neuroscience
- Psychopharmacology
Background:
- An anxiolytic-sensitive human EEG biomarker, goal conflict specific rhythmicity (GCSR), was previously identified using an auditory stop signal task (SST).
- The need exists to adapt GCSR assessment for individuals with hearing impairments.
Purpose of the Study:
- To investigate the feasibility of using a visual SST to measure GCSR.
- To determine if a visual SST can elicit an anxiolytic-sensitive GCSR response.
Main Methods:
- A visual stop signal task (SST) was administered.
- Electroencephalography (EEG) was recorded to measure GCSR.
- Participants received anxiolytic medications (buspirone, triazolam) or placebo.
- Correlations with neuroticism, trait anxiety, and Behavioural Inhibition System scores were assessed.
Main Results:
- The visual SST successfully generated GCSR in the 4-12Hz band at the F8 site, indicating an anxiolytic-sensitive biomarker.
- GCSR was less pronounced than in auditory SSTs, potentially due to response instability.
- Positive GCSR was reduced by buspirone and triazolam, while negative GCSR increased.
- Contrary to predictions, neuroticism, trait anxiety, and BIS scores did not consistently correlate with GCSR.
Conclusions:
- A visual SST can elicit an anxiolytic-sensitive GCSR, offering a potential alternative for individuals with hearing impairments.
- The visual SST requires further refinement to enhance the extent of GCSR and clarify its relationship with personality traits for quantitative equivalence with auditory SSTs.
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