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Histologic Features Associated with Deep Invasion in Dermatofibrosarcoma Protuberans.

C Serra-Guillén1, B Llombart1, E Nagore1

  • 1Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

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|March 6, 2016
PubMed
Summary

Histologic features like sheetlike patterns, cellular pleomorphism, and mitotic figures predict deep invasion in dermatofibrosarcoma protuberans (DFSP). Understanding these can help assess local aggressiveness in DFSP.

Keywords:
Características histológicasDermatofibrosarcoma protuberansHistologic featuresInfiltraciónInvasion

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Area of Science:

  • Dermatopathology
  • Surgical Oncology
  • Oncologic Histology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing skin tumor.
  • DFSP can exhibit aggressive local invasion into deeper tissues.

Purpose of the Study:

  • To identify specific histologic features of DFSP associated with increased invasion depth.
  • To correlate histological findings with local aggressiveness in DFSP.

Main Methods:

  • Analysis of 155 DFSP cases.
  • Evaluation of histologic features including pattern, cellularity, and mitotic activity.
  • Assessment of association between histology and muscle fascia involvement.

Main Results:

  • Sheetlike pattern, high cellular pleomorphism, and increased mitotic figures (>1) were linked to muscle fascia involvement.
  • 62.6% of DFSP remained superficial; 11% involved fascia, and 23.2% invaded muscle.
  • Histologic features significantly predicted deep tissue invasion.

Conclusions:

  • Histologic patterns, pleomorphism, and mitotic rate are key predictors of deep DFSP invasion.
  • Fascia or muscle involvement occurs in up to 30% of DFSP cases.
  • These histological markers aid in assessing DFSP local aggressiveness.