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lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

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Updated: Mar 24, 2026

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

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βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.

Luis Arnes¹, Ildem Akerman², Dina A Balderes¹

¹Department of Genetics and Development, Columbia University, New York, New York 10032, USA;

Genes & Development

|March 6, 2016

Summary

A newly discovered long noncoding RNA, βlinc1, is essential for pancreatic beta cell development and function. Its absence disrupts insulin production and glucose homeostasis, leading to diabetes-like conditions in mice.

Keywords:

long noncoding RNA pancreas development β cell

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Last Updated: Mar 24, 2026

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RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

Area of Science:

Endocrinology
Molecular Biology
Genetics

Background:

Pancreatic beta cells regulate glucose homeostasis; their dysfunction causes diabetes mellitus.
Long noncoding RNAs (lncRNAs) are implicated in development and disease, but their role in pancreas development is largely unexplored.
In vivo investigation of lncRNAs in pancreatic beta cell development is lacking.

Purpose of the Study:

To investigate the in vivo role of lncRNAs in pancreas development.
To identify specific lncRNAs crucial for pancreatic beta cell specification and function.
To elucidate the regulatory mechanisms of identified lncRNAs in beta cell development.

Main Methods:

In vivo studies in mouse models.
Genetic deletion of the βlinc1 gene.
Analysis of islet development and beta cell function.
Assessment of glucose homeostasis.
Investigation of gene regulation by βlinc1.

Main Results:

βlinc1 (beta-cell long intergenic noncoding RNA 1), a conserved lncRNA, is essential for pancreatic beta cell specification and function.
βlinc1 coordinates the regulation of multiple islet-specific transcription factors.
Deletion of βlinc1 leads to impaired islet development.
Loss of βlinc1 disrupts glucose homeostasis in adult mice.

Conclusions:

βlinc1 is a critical regulator of pancreatic beta cell development and function.
βlinc1 acts by coordinating the expression of key islet transcription factors.
Dysregulation of βlinc1 contributes to diabetes mellitus by impairing beta cell function and glucose homeostasis.