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Three-Dimensional Quantitative Evaluation of the Segmental Functional Reserve in the Cirrhotic Liver Using
Canhong Xiang1, Yingmao Chen, Mingzhe Shao
1From the Center for Hepatopanreatobiliary Diseases (CX, XH, LG, AL, JD), Beijing Tsinghua Changguang Hospital, Tsinghua University Medical Center, Changping District, Beijing; Hospital & Institute of Hepato-Biliary Surgery (CX, WD, JD, AZ), Chinese PLA General Hospital, Haidian District, Beijing; and Department of Nuclear Medicine (YC, MS, CL), Chinese PLA General Hospital, Haidian District, Beijing, China.
Functional liver density (FLD) quantitatively assesses regional liver function in cirrhosis. FLD, unlike GSA-K, effectively indicates diminished liver function due to portal obstruction or tumor compression.
Area of Science:
- Hepatology
- Medical Imaging
- Quantitative Analysis
Background:
- Cirrhotic liver disease impairs regional liver function.
- Accurate quantitative assessment of segmental liver function is crucial for treatment planning.
Purpose of the Study:
- To quantitatively evaluate regional functional reserve in cirrhotic livers.
- To identify an index reflecting diminished segmental liver function.
Main Methods:
- Utilized a 3D system to fuse technetium-99m galactosyl human serum albumin SPECT and CT images.
- Calculated parameters including functional liver density (FLD) and GSA-K.
- Compared FLD and GSA-K in different intrahepatic segments across patient groups and controls.
Main Results:
- Overall FLD was significantly lower in cirrhotic patients compared to controls.
- FLD in the right hemiliver was significantly lower in patients with tumor embolus.
- FLD was significantly lower in tumor-bearing segments compared to tumor-free segments.
- No significant differences in GSA-K were observed in intrahepatic segments.
Conclusions:
- Segmental liver functional reserve can be quantitatively calculated.
- FLD is a reliable index for diminished regional liver function caused by portal flow obstruction or tumor compression.
- GSA-K does not reflect diminished regional liver function in this context.
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