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Transmembrane signalling at the epidermal growth factor receptor
Trends in Pharmacological Sciences
|October 1, 1989
Abstract:
The EGF receptor, which is homologous to the v-erb-B oncogene product, has intrinsic tyrosine kinase activity, and mediates an increase in polyphosphoinositide turnover and [Ca2+]i. Recently, great progress has been made in understanding the mechanism of signal transduction at this receptor. Jacopo Meldolesi and colleagues discuss how this knowledge may lead to a better understanding of the control of cell proliferation.
Insights
Epidermal Growth Factor (EGF) receptor tyrosine kinase activity influences cell proliferation. Understanding its signal transduction mechanisms is key to controlling cell growth.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- The Epidermal Growth Factor (EGF) receptor shares homology with the v-erb-B oncogene product.
- This receptor possesses intrinsic tyrosine kinase activity.
- EGF receptor signaling is implicated in cellular processes beyond proliferation.
Purpose of the Study:
- To review recent advancements in understanding EGF receptor signal transduction.
- To explore the implications of this knowledge for controlling cell proliferation.
Main Methods:
- Review of current literature on EGF receptor signaling pathways.
- Discussion of biochemical and cellular mechanisms involved in signal transduction.
Main Results:
- The EGF receptor mediates increased polyphosphoinositide turnover.
- EGF receptor activation leads to an increase in intracellular calcium ([Ca2+]i).
- Significant progress has been made in elucidating the receptor's signal transduction mechanisms.
Conclusions:
- Understanding EGF receptor signaling is crucial for comprehending cell proliferation control.
- Further research into EGF receptor pathways may yield therapeutic targets for proliferative diseases.